All-Cause and Cause-Specific Mortality among Users of Basal Insulins NPH, Detemir, and Glargine
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چکیده
منابع مشابه
Differential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 Diabetes Mellitus
OBJECTIVE To assess the role of adiposity on the pharmacodynamics of basal insulins NPH, detemir, and glargine in type 2 diabetes mellitus (T2DM), as estimated by glucose infusion rate (GIR) and endogenous glucose production (EGP) rate in the euglycemic clamp. RESEARCH DESIGN AND METHODS We examined the variables that best predicted GIR and EGP in 32-h clamp studies after treatment with subcu...
متن کاملDifferential Effects of Adiposity on Pharmacodynamics of Basal Insulins NPH, Glargine, and Detemir in Type 2 Diabetes
We have shown that the pharmacokinetics and pharmacodynamics (PD) of basal insulins neutral protamine Hagedorn insulin (NPH), detemir, and glargine, when examined (euglycemic clamp), differ in subjects with type 2 diabetes mellitus (T2DM) (1). The primary PD end point parameter, the glucose infusion rate (GIR) over the 32 h of clamp study, was greater with glargine versus NPH and detemir. We ca...
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متن کاملPharmacokinetics and Pharmacodynamics of Therapeutic Doses of Basal Insulins NPH, Glargine, and Detemir After 1 Week of Daily Administration at Bedtime in Type 2 Diabetic Subjects
OBJECTIVE To compare the pharmacokinetics and pharmacodynamics of NPH, glargine, and detemir insulins in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS This study used a single-blind, three-way, cross-over design. A total of 18 type 2 diabetic subjects underwent a euglycemic clamp for 32 h after a subcutaneous injection of 0.4 units/kg at 2200 h of either NPH, glargine, or detemir afte...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0151910